| 11 | 1 | 1 | Canyon Crest Academy | San Dieguito Union High | 2,336 | 87.2% | 91.93% | 82.54% | 8.7 |
| 20 | 1 | 2 | Westview High | Poway Unified | 2,257 | 81.9% | 92.02% | 71.72% | 8.2 |
| 34 | 1 | 3 | Scripps Ranch High | San Diego Unified | 1,984 | 78.5% | 84.21% | 72.75% | 7.8 |
| 82 | 2 | 4 | Torrey Pines High | San Dieguito Union High | 2,614 | 70.7% | 81.64% | 59.84% | 7.1 |
| 102 | 2 | 5 | Rancho Bernardo High | Poway Unified | 2,318 | 68.7% | 79.44% | 57.97% | 6.9 |
| 122 | 3 | 6 | Mt. Carmel High | Poway Unified | 1,865 | 66.1% | 73.97% | 58.21% | 6.6 |
| 167 | 2 | 7 | Mira Mesa High | San Diego Unified | 2,219 | 62.6% | 79.47% | 45.68% | 6.3 |
| 182 | 4 | 8 | University City High | San Diego Unified | 1,543 | 61.2% | 74.26% | 48.13% | 6.1 |
| 195 | 5 | 9 | Henry High | San Diego Unified | 2,607 | 60.2% | 73.6% | 46.76% | 6.0 |
| 209 | 1 | 10 | High Tech High Mesa Charter | High Tech High Mesa District | 434 | 59.3% | 77.55% | 41.0% | 5.9 |
| 223 | 1 | 11 | School for Entrepreneurship and Technology Charter | School for Entrepreneurship and Technology District | 228 | 58.5% | 77.97% | 38.98% | 5.8 |
| 256 | 6 | 12 | Kearny Eng Innov & Design | San Diego Unified | 311 | 56.1% | 80.7% | 31.58% | 5.6 |
| 271 | 1 | 13 | High Tech High Charter | High Tech High District | 521 | 55.2% | 70.83% | 39.58% | 5.5 |
| 290 | 7 | 14 | Mission Bay High | San Diego Unified | 1,169 | 54.2% | 71.81% | 36.54% | 5.4 |
| 310 | 8 | 15 | Kearny School of Biomedical Science and Technology | San Diego Unified | 332 | 52.7% | 66.67% | 38.81% | 5.3 |
| 317 | 9 | 16 | Kearny College Connections | San Diego Unified | 357 | 52.2% | 70.0% | 34.44% | 5.2 |
| 399 | 10 | 17 | Kearny Digital Media & Design | San Diego Unified | 344 | 47.5% | 74.68% | 20.25% | 4.8 |
| 452 | 11 | 18 | Point Loma High | San Diego Unified | 1,714 | 44.9% | 56.87% | 32.88% | 4.5 |
| 499 | 12 | 19 | San Diego SCPA | San Diego Unified | 1,231 | 42.7% | 55.45% | 29.94% | 4.3 |
| 606 | 6 | 20 | Montgomery Senior High | Sweetwater Union High | 1,745 | 39.1% | 59.95% | 18.23% | 3.9 |
| 624 | 1 | 21 | High Tech High Media Arts Charter | High Tech High Media Arts District | 389 | 38.5% | 55.0% | 22.0% | 3.9 |
| 642 | 13 | 22 | Morse High | San Diego Unified | 1,675 | 37.8% | 56.0% | 19.66% | 3.8 |
| 681 | 5 | 23 | Del Norte High | Poway Unified | 2,531 | 36.6% | 50.88% | 22.35% | 3.7 |
| 718 | 1 | 24 | High Tech High International Charter | High Tech High International District | 396 | 35.6% | 45.56% | 25.56% | 3.6 |
| 740 | 14 | 25 | Canyon Hills High | San Diego Unified | 1,307 | 34.6% | 44.72% | 24.4% | 3.5 |
| 764 | 15 | 26 | Clairemont High | San Diego Unified | 835 | 34.0% | 44.38% | 23.6% | 3.4 |
| 765 | 1 | 27 | e3 Civic High Charter | e3 Civic High District | 398 | 34.0% | 47.44% | 20.51% | 3.4 |
| 779 | 16 | 28 | Lincoln High | San Diego Unified | 1,407 | 33.6% | 43.88% | 23.38% | 3.4 |
| 794 | 17 | 29 | San Diego High | San Diego Unified | 2,105 | 33.2% | 46.65% | 19.83% | 3.3 |
| 817 | 1 | 30 | King-Chavez Community High Charter | King-Chavez Community High District | 258 | 32.5% | 52.94% | 12.0% | 3.2 |
| 824 | 1 | 31 | Health Sciences High and Middle College Charter | Health Sciences High District | 525 | 32.4% | 47.71% | 16.99% | 3.2 |
| 905 | 8 | 32 | Southwest Senior High | Sweetwater Union High | 1,645 | 30.3% | 48.26% | 12.43% | 3.0 |
| 932 | 18 | 33 | Crawford High | San Diego Unified | 1,193 | 29.3% | 47.91% | 10.78% | 2.9 |
| 1003 | 19 | 34 | Madison High | San Diego Unified | 944 | 26.4% | 39.9% | 13.0% | 2.6 |
| 1026 | 1 | 35 | Gompers Preparatory Academy Charter | Gompers Preparatory Academy District | 1,279 | 25.8% | 39.17% | 12.48% | 2.6 |
| 1048 | 20 | 36 | Hoover High | San Diego Unified | 2,265 | 24.8% | 41.58% | 8.03% | 2.5 |
| 1061 | 12 | 37 | San Ysidro High | Sweetwater Union High | 2,316 | 24.4% | 34.45% | 14.43% | 2.4 |
| 1190 | 1 | 38 | San Diego Mission Academy Charter | San Diego Mission Academy District | 151 | 17.1% | 25.32% | 8.97% | 1.7 |
| 1231 | 1 | 39 | Ingenuity Charter Charter | Ingenuity Charter District | 154 | 13.5% | 22.52% | 4.42% | 1.4 |
| 1242 | 1 | 40 | City Heights Preparatory Charter Charter | City Heights Preparatory Charter District | 141 | 12.5% | 18.0% | 7.0% | 1.2 |
| None | 1 | 41 | Charter School of San Diego Charter | Charter School of San Diego District | 1,415 | — | — | — | — |
| None | 1 | 42 | Urban Corps of San Diego County Charter Charter | Mono County Office of Education | 183 | — | — | — | — |